Descemet membrane rupture accompanied by stromal clefting in congenital glaucoma.

Comment. Bevacizumab in this patient was shown to be well tolerated without any signs of toxic effects; in particular, no inflammation, degeneration, or necrosis was observed. Furthermore, the results show that bevacizumab effectively controlled the neovascularization in zone 1, stage 2 ROP. Vascular endothelial growth factor is a survival factor for retinal neurons and a critical neuroprotectant during the adaptive response to ischemic injury. The retina and the proliferating abnormal vessels showed high levels of VEGF expression at both messenger RNA and protein levels. Vascular endothelial growth factor has recently been shown to influence neuronal growth, differentiation, and survival owing to its neurotrophic effects. Therefore, the dosage of bevacizumab is critical to preserve this effect on the neuroretina for adequate development. In our case, we administered 40% of the adult dose twice. Our results show preservation of morphology and expression of VEGF in the retina.